Assessment of effective absorbed dose of (111)In-DTPA-Buserelin in human on the basis of biodistribution rat data.
Identifieur interne : 000868 ( Main/Exploration ); précédent : 000867; suivant : 000869Assessment of effective absorbed dose of (111)In-DTPA-Buserelin in human on the basis of biodistribution rat data.
Auteurs : RBID : pubmed:22874898English descriptors
- KwdEn :
- Animals, Buserelin (administration & dosage), Buserelin (diagnostic use), Buserelin (pharmacokinetics), Chelating Agents (administration & dosage), Chelating Agents (diagnostic use), Chelating Agents (pharmacokinetics), Fertility Agents, Female (administration & dosage), Fertility Agents, Female (diagnostic use), Fertility Agents, Female (pharmacokinetics), Humans, Indium Radioisotopes (administration & dosage), Indium Radioisotopes (diagnostic use), Indium Radioisotopes (pharmacokinetics), Injections, Intra-Arterial, Models, Biological, Organ Specificity, Pentetic Acid (administration & dosage), Pentetic Acid (diagnostic use), Pentetic Acid (pharmacokinetics), Radiation Dosage, Radiometry, Radiopharmaceuticals (administration & dosage), Radiopharmaceuticals (diagnostic use), Radiopharmaceuticals (pharmacokinetics), Rats, Tissue Distribution.
- MESH :
- chemical , administration & dosage : Buserelin, Chelating Agents, Fertility Agents, Female, Indium Radioisotopes, Pentetic Acid, Radiopharmaceuticals.
- chemical , diagnostic use : Buserelin, Chelating Agents, Fertility Agents, Female, Indium Radioisotopes, Pentetic Acid, Radiopharmaceuticals.
- chemical , pharmacokinetics : Buserelin, Chelating Agents, Fertility Agents, Female, Indium Radioisotopes, Pentetic Acid, Radiopharmaceuticals.
- Animals, Humans, Injections, Intra-Arterial, Models, Biological, Organ Specificity, Radiation Dosage, Radiometry, Rats, Tissue Distribution.
Abstract
In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of (111)In-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. From rat data, it was estimated that a 185-MBq injection of (111)In-DTPA-Buserelin into the human might result in an estimated absorbed dose of 24.27 mGy to the total body and the highest effective absorbed dose was in kidneys, 28.39 mSv. The promising results of this study emphasises the importance of absorbed doses in humans estimated from data on rats.
DOI: 10.1093/rpd/ncs137
PubMed: 22874898
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of effective absorbed dose of (111)In-DTPA-Buserelin in human on the basis of biodistribution rat data.</title><author><name sortKey="Lahooti, Afsaneh" uniqKey="Lahooti A">Afsaneh Lahooti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, 16 Azar Street, Tehran, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, 16 Azar Street, Tehran</wicri:regionArea></affiliation></author><author><name sortKey="Shanehsazzadeh, Saeed" uniqKey="Shanehsazzadeh S">Saeed Shanehsazzadeh</name></author><author><name sortKey="Jalilian, Amir Reza" uniqKey="Jalilian A">Amir Reza Jalilian</name></author><author><name sortKey="Tavakoli, Mohammad Bagher" uniqKey="Tavakoli M">Mohammad Bagher Tavakoli</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.1093/rpd/ncs137</idno><idno type="RBID">pubmed:22874898</idno><idno type="pmid">22874898</idno><idno type="wicri:Area/Main/Corpus">000B31</idno><idno type="wicri:Area/Main/Curation">000B31</idno><idno type="wicri:Area/Main/Exploration">000868</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Buserelin (administration & dosage)</term><term>Buserelin (diagnostic use)</term><term>Buserelin (pharmacokinetics)</term><term>Chelating Agents (administration & dosage)</term><term>Chelating Agents (diagnostic use)</term><term>Chelating Agents (pharmacokinetics)</term><term>Fertility Agents, Female (administration & dosage)</term><term>Fertility Agents, Female (diagnostic use)</term><term>Fertility Agents, Female (pharmacokinetics)</term><term>Humans</term><term>Indium Radioisotopes (administration & dosage)</term><term>Indium Radioisotopes (diagnostic use)</term><term>Indium Radioisotopes (pharmacokinetics)</term><term>Injections, Intra-Arterial</term><term>Models, Biological</term><term>Organ Specificity</term><term>Pentetic Acid (administration & dosage)</term><term>Pentetic Acid (diagnostic use)</term><term>Pentetic Acid (pharmacokinetics)</term><term>Radiation Dosage</term><term>Radiometry</term><term>Radiopharmaceuticals (administration & dosage)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Radiopharmaceuticals (pharmacokinetics)</term><term>Rats</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Buserelin</term><term>Chelating Agents</term><term>Fertility Agents, Female</term><term>Indium Radioisotopes</term><term>Pentetic Acid</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Buserelin</term><term>Chelating Agents</term><term>Fertility Agents, Female</term><term>Indium Radioisotopes</term><term>Pentetic Acid</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Buserelin</term><term>Chelating Agents</term><term>Fertility Agents, Female</term><term>Indium Radioisotopes</term><term>Pentetic Acid</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Injections, Intra-Arterial</term><term>Models, Biological</term><term>Organ Specificity</term><term>Radiation Dosage</term><term>Radiometry</term><term>Rats</term><term>Tissue Distribution</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of (111)In-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. From rat data, it was estimated that a 185-MBq injection of (111)In-DTPA-Buserelin into the human might result in an estimated absorbed dose of 24.27 mGy to the total body and the highest effective absorbed dose was in kidneys, 28.39 mSv. The promising results of this study emphasises the importance of absorbed doses in humans estimated from data on rats.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22874898</PMID><DateCreated><Year>2013</Year><Month>03</Month><Day>19</Day></DateCreated><DateCompleted><Year>2013</Year><Month>09</Month><Day>10</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1742-3406</ISSN><JournalIssue CitedMedium="Internet"><Volume>154</Volume><Issue>1</Issue><PubDate><Year>2013</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Radiation protection dosimetry</Title><ISOAbbreviation>Radiat Prot Dosimetry</ISOAbbreviation></Journal><ArticleTitle>Assessment of effective absorbed dose of (111)In-DTPA-Buserelin in human on the basis of biodistribution rat data.</ArticleTitle><Pagination><MedlinePgn>1-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/rpd/ncs137</ELocationID><Abstract><AbstractText>In this study, the effective absorbed dose to human organs was estimated, following intra vascular administration of (111)In-DTPA-Buserelin using biodistribution data from rats. Rats were sacrificed at exact time intervals of 0.25, 0.5, 1, 2, 4 and 24 h post injections. The Medical Internal Radiation Dose formulation was applied to extrapolate from rats to humans and to project the absorbed radiation dose for various human organs. From rat data, it was estimated that a 185-MBq injection of (111)In-DTPA-Buserelin into the human might result in an estimated absorbed dose of 24.27 mGy to the total body and the highest effective absorbed dose was in kidneys, 28.39 mSv. The promising results of this study emphasises the importance of absorbed doses in humans estimated from data on rats.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lahooti</LastName><ForeName>Afsaneh</ForeName><Initials>A</Initials><Affiliation>Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, 16 Azar Street, Tehran, Iran.</Affiliation></Author><Author ValidYN="Y"><LastName>Shanehsazzadeh</LastName><ForeName>Saeed</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Jalilian</LastName><ForeName>Amir Reza</ForeName><Initials>AR</Initials></Author><Author ValidYN="Y"><LastName>Tavakoli</LastName><ForeName>Mohammad Bagher</ForeName><Initials>MB</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>08</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Radiat Prot Dosimetry</MedlineTA><NlmUniqueID>8109958</NlmUniqueID><ISSNLinking>0144-8420</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Chelating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Fertility Agents, Female</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>7A314HQM0I</RegistryNumber><NameOfSubstance>Pentetic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>PXW8U3YXDV</RegistryNumber><NameOfSubstance>Buserelin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Buserelin</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Chelating Agents</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Fertility Agents, Female</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Injections, Intra-Arterial</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Organ Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pentetic Acid</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiation Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName><QualifierName MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>8</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>9</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">ncs137</ArticleId><ArticleId IdType="doi">10.1093/rpd/ncs137</ArticleId><ArticleId IdType="pubmed">22874898</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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